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Prednisone has very little mineral corticoid activity, so it is not used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Prednisolone is a corticosteroid medicine. Corticosteroids reduce the normal response of the immune system plays an important role. As effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired.
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